Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetP-glycoprotein-expressing multidrug resistant (MDR) cells

Target IC₅₀: 2 nM for MDR CCRF-CEM/VBL100 cells

General description

A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC₅₀ = 2 nM for MDR CCRF-CEM/VBL₁₀₀ cells).

A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multi drug resistant (MDR) cells (IC₅₀ = 2 nM for MDR CCRF-CEM/VBL₁₀₀ cells).

Legal Information

Not available for sale in Germany.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Giannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2904.Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.Nicolaou, K.C., et al. 1997. Nature 387, 268.Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.

Packaging

1 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

Warning

Toxicity: Toxic & Carcinogenic / Teratogenic (G)